PF06463922勞拉替尼價格咨詢武漢新百川醫藥
PF06463922勞拉替尼生產廠家就找武漢新百川醫藥
PF06463922勞拉替尼供應商武漢新百川醫藥更專業
PF06463922勞拉替尼哪里有?武漢新百川醫藥有現貨
PF06463922勞拉替尼哪家工廠生產?武漢新百川醫藥專業生產
PF06463922勞拉替尼現貨,PF06463922純度,PF06463922含量,PF06463922價格,
PF06463922勞拉替尼生產廠家就找武漢新百川醫藥
PF06463922勞拉替尼供應商武漢新百川醫藥更專業
PF06463922勞拉替尼哪里有?武漢新百川醫藥有現貨
PF06463922勞拉替尼哪家工廠生產?武漢新百川醫藥專業生產
PF06463922勞拉替尼現貨,PF06463922純度,PF06463922含量,PF06463922價格,
PF06463922勞拉替尼
CAS NO. 1454846-35-5
英文品名? PF-06463922
分子式 C21H19FN6O2
分子量 406.15
規格/純度 99%
供應能力 can supply g scale
別名? PF 06463922;PF06463922
產品簡述? PF-06463922 is a novel, orally available, CNS-penetrant, ATP-competitive inhibitor of ALK/ROS1 with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively.
詳細說明 PF-06463922 demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. PF-06463922 exhibited subnanomolar cellular potency against oncogenic ROS1 fusions and inhibited the crizotinib-refractory ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation. Compared with crizotinib and the second-generation ALK/ROS1 inhibitors ceritinib and alectinib, PF-06463922 showed significantly improved inhibitory activity against ROS1 kinase. in vivo: PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. Furthermore, PF-06463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblastoma.
詳細說明 PF-06463922 demonstrates significant cell activity against ALK and a large set of ALK clinical mutations with IC50 ranging from 0.2 nM-77 nM. PF-06463922 exhibited subnanomolar cellular potency against oncogenic ROS1 fusions and inhibited the crizotinib-refractory ROS1(G2032R) mutation and the ROS1(G2026M) gatekeeper mutation. Compared with crizotinib and the second-generation ALK/ROS1 inhibitors ceritinib and alectinib, PF-06463922 showed significantly improved inhibitory activity against ROS1 kinase. in vivo: PF-06463922 showed marked antitumor activity in tumor models expressing FIG-ROS1, CD74-ROS1, and the CD74-ROS1(G2032R) mutation. Furthermore, PF-06463922 demonstrated antitumor activity in a genetically engineered mouse model of FIG-ROS1 glioblastoma.
新百川醫藥替尼類新型抗腫瘤小分子抑制劑:馬來酸,,,,蘋果酸,阿西替尼,托法替尼,,魯索替尼,巴瑞克替尼,色瑞替尼,,多韋替尼,司美替尼,達克替尼(Dacomitinib,PF299804),PF0643922;勞拉替尼,布格替尼Brigatinib,,替沃扎尼475108-18-0
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