6-氨基-1,3-二甲基尿嘧啶6-Amino-1,3-dimethyluracil(DMAU)

用途Application:

6-氨基-1,3-二甲基尿嘧啶(6-氨基-1,3-二甲基脲嘧啶)，用于API的合成，也广泛用于PVC热稳定剂的原辅料；

6-Amino-1,3-dimethyluracil(DMAU),?in?pharmaceutical?industry,?use?it?in?synthesis?of?Theophylline?and?etc.;?

also?can be?widely?used?as?ingredient?for?PVC?heat?stabilizer;

简介Capacity：

该产品是我公司的主打产品之一，我公司为该产品大生产商，有欧盟REACH正式注册；It?is?our?strong?product,?we?are?the?leading?manufacturer?of?it,?have?formal?EU-REACH?registration;

技术说明书Technical?Data?Sheet：

化学名：6-氨基-1,3-二甲基尿嘧啶(6-氨基-1,3-二甲基脲嘧啶)

Chemical?Name:?6-Amino-1,3-dimethyluracil(DMAU)

分子式Formula:?C6H9N3O2

分子量MW:?155.16

Cas#:?6642-31-5

结构式Structure?Formula:

物理特性Physical?Properties:

颜色Color:?类白色到淡黄色粉末off-white?to?light?yellow?powder;

20degC下比重Specific?Gravity?at?20degC:?无N/A;

规格Specifications:

含量Assay:?大于99.0%?min.;

干燥失重loss?on?drying:?小于1%max.;

粒度Particle?size,?45μm:?大于99%min.;

包装Packing:?25kgs塑编袋25kgs?plastic?woven?bag;

产品作用原理mechanism：

一、6-氨基-1,3-二甲基尿嘧啶（简称DMAU）作用原理:

熔点高达290℃以上，200℃加热减量＜1%，本身特性能够适应PVC生产过程。?DMAU能吸收PVC生产过程

中产生的HCl，还能取代不稳定的Cl原子。与ZnSt2共同使用时，?DMAU能与ZnCl2发生反应，生成金属络合

物，使ZnCl2失去活性，能防止“锌烧”，大大增强PVC样品的长期稳定性；DMAU中主要基团尿嘧啶是人体

必需的四种核苷酸之一，对人体安全无害；DMAU因此被认为是高效且安全的热稳定剂；

A.?Mechanism:

with?melting?point?of?more?than?290degC,?loss?on?drying?under?200degC?of?less?than?1%,?it?suits?for?

PVC’s?producing?process.?Can?absorb?HCl?which?is?by-produced?during?producing?process?of?PVC,?can?replace?Cl-?which?is?not?stable.?When?be?used?with?

ZnSt2,?can?react?with?ZnCl2?to?create?metal?complex,?then?ZnCl2?losses?its?activity,?so?can?avoid?PVC’s?

color?from?changing?into?darker,?improve?PVC’s?long?term?stability;?Its?basic?chemical?structure?‘uracil’?is?

one?of?the?essential?nucleotides?of?the?human?body,?has?no?hazardous?to?human;?So?it?is?taken?as?PVC?

heat?stabilizer?of?high-efficiency?and?safety;

二、DMAU与ZnSt2:

含有DMAU/ZnSt2复合稳定剂，无论初期白度还是长期稳定性都比含有CaSt2/ZnSt2复合稳定剂的更好。

DMAU与ZnSt2共同使用时具有良好的系统稳定效果，比目前工业上常用的的协同效果更好；

B.?DMAU?and?ZnSt2:

Stabilizer?of?DMAU/ZnSt2?is?better?than?stabilizer?of?CaSt2/ZnSt2?on?both?initial?whiteness?and?long?term?

stability;?DMAU/ZnSt2?is?of?systematic?stability,?its?efficiency?is?better?than?that?of?CaSt2/ZnSt2,?which?is?

of?synergistic?stability;

三、?DMAU与水滑石（或沸石）:

DMAU与水滑石（或沸石，沸石更节省成本）同时使用，在钙锌稳定剂的配方中，加入3-4%的DMAU和

8-10%的水滑石或沸石，能更好地抑制PVC初期着色度，该配方更加经济可靠；

C.?DMAU?and?Hydrotalcite(or?Aluminosilicate):

To?add?3-4%?of?DMAU?and?8-10%?hydrotalcite(or?Aluminosilicate,?whose?cost?is?lower)?into?Calcium/Zinc?stabilizer,?it?can?improve?

PVC’s?initial?colorless,?and?is?more?economic;

四、DMAU与β-二酮:

DMAU与β-二酮都是新兴的有机稳定剂，两者单独进行比较，DMAU在抑制初期着色和长期热稳定性方面

都能更胜一筹。实际生产过程中DMAU既可以完全替代β-二酮，也可以与β-二酮共同使用；

D.?DMAU?and?Stearoyl?benzoyl?methane:

DMAU?can?improve?PVC’s?initial?colorless?and?long?term?heat?stability,?so?is?Stearoyl?benzoyl?methane;

?when?preparing?PVC?stabilizer,?DMAU?can?replace?stearoyl?benzoyl?methane,?DMAU?can?be?used?together?

with?stearoyl?benzoyl?methane?also;

五、DMAU发展历程:

DMAU应用于PVC稳定剂的技术早是由美国Chemtura研发，其将DMAU广泛的应用于其各种无铅稳定剂的

配方中。随着对铅盐稳定剂的限制，DMAU作为无铅稳定剂中的新星。新华制药是国内外大的DMAU

生产商。

E.?History?of?DMAU:

The?world?main?producers?of?PVC?stabilizer?are?cooperating?with?us.?Accompany?more?and?more?countries

?forbid?to?use?lead?salts?PVC?stabilizer,?it?will?be?used?more?and?more?widely;?We?are?the?leading?

manufacturer?of?DMAU.?